Frank's Lab - Cryo-EM of molecular machines, ...
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We are interested in establishing direct correlation between the biochemical states and the conformations of molecular machinery, while they are performing their tasks. Our main tools are cryo-electron microscopy (cryo-EM), which enables the structure determination of proteins near native conditions and optical spectroscopy, which has the ability to detect and characterize ligands on a single molecule level. In order to achieve our goals, we are developing strategies to combine the...
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