What is a Skin Lesion? A skin lesion is any growth on the skin that looks different or abnormal when compared the skin that surrounds it. These growths can immediately cause panic and worry. Ecobeautica understands what beauty and health means to people. It can be in shape of a different colored, sore or lumped area of the skin. In this case, skin lesion removal, as well as skin lesion biopsy is the treatment to go for.